ea0022p401 | Endocrine tumours & neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010
Esposito Francesco
, Franco Renato
, Fedele Monica
, Fusco Alfredo
, Chieffi Paolo
, Bosica Francesca
PATZ1 is a recently discovered zinc finger protein that, due to the presence of the POZ domain, acts as a transcriptional repressor affecting the basal activity of different promoters, and associates with a variety of transcription factors (i.e. RNF4, HMGA1, gscl, SPBP). We have previously described, by using mice lacking the PATZ1 gene, its crucial role in spermatogenesis. Consistently, PATZ1-KO mice are unfertile and testes from these mice showed only few spermatocyte...